Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

by: Iola Bonggay

The United States Food and Drug Administration, otherwise referred to as the USFDA, an agency operating within the United States Department of Health and Human Services that is generally responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs, vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices, veterinary products, and cosmetics.

The USFA has recently formed a collaboration with the National Institutes of Health to establish the Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

The primary goal of the program is to develop computational fluid dynamics (CFD) model of orally inhaled drug products that can account for drug product characteristics and physiological parameters on total and regional deposition in the lungs.

This is all in conjunction with the USFDA's objective of developing a CFD model that will be capable of of predicting highly localized deposition of pharmaceutically relevant polydisperse aerosols from metered dose inhalers (MDIs) and dry powder inhalers (DPIs).

In addition, the results that will be derived from this study will then be utilized to create a linked CFD-compartment model that can predict the effects of lung deposition on safety (systemic exposure) and efficacy (local delivery) for locally acting orally inhaled drugs.

  (continued...)

Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.
  Page 2

About The Author Iola Bonggay is an editor of TopGovernmentGrants.com one the the most comprehensive Websites offering information on government grants and federal government programs. She also maintains Websites providing resources on environmental grants and grants for youth programs.

Additional Resources

category - Health Grants

Scale-Up of Care and Support Services for Orphans and Vulnerable Children in Nigeria
The USAID office in Nigeria has recently established a program called Scale-Up of Care and Support Services for Orphans and Vulnerable Children wherein it intends to improve the health and well-being of orphans and vulnerable children in Nigeria by way of developing a sustainable, comprehensive and coordinated program that will potentially help these kids live a normal, and healthy life.

---

Modeling Social Behavior Grant Program
The National Institutes of Health has collaborated with the National Institute of General Medical Sciences (NIGMS) and the National Institute of Mental Health (NIMH) in order to establish the Modeling Social Behavior Grant Program wherein they intend to seek applications for the development and evaluation of innovative theories, as well as computational, mathematical, and engineering approaches that could better our understanding of a human being's social behavior.

---

Health Resources and Services Administration's Licensure Portability Grant Program
The Health Resources and Services Administration has constituted the Licensure Portability Grant Program (LPGP) wherein they aim to improve the experience of State licensing boards that have manifested a credible record in implementing cross-border activities in order to help overcome licensure barriers in the provision of telemedicine services across various States.

---

Competitive Revision for Technology Development Within Biomedical Technology Research Centers Program
The National Institutes of Health has formed a partnership with the National Center for Research Resources (NCRR) in an attempt to establish the Competitive Revision for Technology Development Within Biomedical Technology Research Centers Program.

---